The Trip Report by Beckley Waves
The Trip Report
#20: Jackie von Salm, Ph.D. - Natural Products & Novel Therapies

#20: Jackie von Salm, Ph.D. - Natural Products & Novel Therapies

Welcome back to The Trip Report Podcast, a production of Beckley Waves, a Psychedelic Venture Studio.

This week, I am speaking with Dr. Jackie von Salm, Ph.D., co-founder and Chief Scientific Officer at Psilera, a biotech company pioneering early-stage psychedelic-inspired drug discovery and development for neurological conditions.

If you’ve ever been curious about the intricate and fascinating world of drug discovery, this conversation is a must-listen.

Jackie walks me through the entire process, from scaffolds to IND submission and all the steps in between.

Along the way, we discuss her background in natural product chemistry, the role of secondary metabolites, and a unique property of adaptive physiology whereby some types of stress actually strengthen organisms.

We discuss the origin story of Psilera and the inspiration from 2 Bromo-LSD, a non-hallucinogenic compound that has been successfully used by people suffering from cluster headaches, among other neurological conditions.

We discuss the increasing role of AI and computation in the drug discovery process but also the ‘chemical intuition’ that one develops after years of practicing chemistry. 

We dive into the emerging field of neuropsychiatric biomarkers, a toolset that has eluded researchers, clinicians, and patients in this particular field, and how EEG and other brain imaging technologies may be the answer.

We discuss the perception of psychedelic drug development in the eyes of the pharma world and much more.

And now, I bring you my conversation with Dr. Jackie von Salm.

Listen to the episode on Substack, Spotify, Google or Apple.


Theme music by MANCHO Sounds, Mixed and Mastered by Rollin Weary

The Trip Report by Beckley Waves
The Trip Report
The Trip Report is a podcast and newsletter about the business, science, and policy developments of the evolving psychedelic field. While the main organizing theme is psychedelics, it is really about the many different domains that are converging to bring about this field and the assembly of what many believe to be a “New Paradigm” in science, medicine, and our understanding of the human experience. Our goal is to foster an educated and informed psychedelic ecosystem, and to do that, we will feature in-depth conversations with scientists, entrepreneurs, investors and stakeholders at the forefront of the psychedelic renaissance.